منابع مشابه
Pooled Screening for Synergistic Interactions Subject to Blocking and Noise
The complex molecular networks in the cell can give rise to surprising interactions: gene deletions that are synthetically lethal, gene overexpressions that promote stemness or differentiation, synergistic drug interactions that heighten potency. Yet, the number of actual interactions is dwarfed by the number of potential interactions, and discovering them remains a major problem. Pooled screen...
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Protein-protein interactions (PPIs) are emerging as a promising new class of drug targets. Here, we present a novel high-throughput approach to screen inhibitors of PPIs in cells. We designed a library of 50,000 human peptide-binding motifs and used a pooled lentiviral system to express them intracellularly and screen for their effects on cell proliferation. We thereby identified inhibitors tha...
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Recent investigations of the antigenic relationships of all Paracolobactrum cultures isolated in the Florida State Board of Health, Jacksonville, laboratory during 1946 and 1947 (Stuart, Galton, and McGann: J. Bact., 46, 411, 1948) revealed that 40 per cent of these cultures were Paracolobactrum intermedium. It was also found that many of the P. intermedium cultures belonged to the Bethesda gro...
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Components of the type II CRISPR-Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic screens. Such developments are providing new opportunities for drug target identification and validation, particularly with the application of pooled genetic screening. As CRISPR-Cas is a r...
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Screening for ocular disease and visual dysfunction in children has been conducted at different levels and to varying extent in different countries of the world. There are two main periods in a child’s life that are of special interest. In the neonatal period detection of organic disease such as congenital cataract and retinopathy of prematurity (ROP) is important. Screening for congenital cata...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2020
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20209640